Description
Tropomyosin-related kinase B (TrkB) is a receptor for neurotrophins, a family of closely related proteins that are important physiological regulators of the survival of specific neurons within the peripheral nervous system (PNS) of vertebrates.1 TrkB is an independent prognostic marker in patients with gastric cancer and appears to be associated with metastatic potential.2 Trk-B pathway down-regulation may be the major pathogenesis for Major depressive disorder (MDD).2